Syntheses of (rac)3-substituted 4-methoxycarbonyl-1,3-thiazolidine-2-thiones via rearrangement of a substituted group from exo-S to N in (rac)2-substituted thio-4-methoxycarbonyl-.DELTA.2-1,3-thiazolines.
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چکیده
منابع مشابه
Synthesis of Substituted 2-Benzoylaminothiobenzamides and Their Ring Closure to Substituted 2-Phenylquinazoline-4- thiones
Acylation of 2-aminothiobenzamide or 2-methylaminothiobenzamide with substituted benzoyl chlorides has been used to synthesise the corresponding 2-benzoylaminothiobenzamides whose subsequent sodium methoxide-catalysed ring closure gives the corresponding quinazoline-4-thiones. These compounds were characterised by means of their Hand C-NMR spectra. The preferred tautomeric form of selected comp...
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Pathogenic infections and inflammation are very common ailments humans suffer. Upsurge of resistant pathogens has impeded the antimicrobial drug development process in recent years and the search of new antimicrobial agents is clearly evident from the literature. In line with these developments the synthesis of N-substituted aryl-2-({4-[(substituted aryl carbamoyl) methyl]-5-(pyridin-4-yl)-4H-1...
متن کاملMicrowave-assisted synthesis and evaluation of N-substituted thiazolidine-2, 4-dione derivatives as antimicrobial agents
A series of N-substituted thiazolidine-2,4-dione derivatives bearing potentially bioactive substituents were synthesized by microwave irradiation method. Structural elucidation was accomplished by 1H NMR, 13C NMR, IR, Mass and elemental analyses. The synthesized compounds were evaluated for antimicrobial activities. Among the compounds studied, compounds 4i and 4d showed potent antimicrobial ac...
متن کاملSynthesis and potential antimycotic activity of 4-substituted-3-(thiophene-2-yl-methyl)-Delta2-1,2,4-triazoline-5-thiones.
In the reaction of hydrazide of thiophene-2-acetic acid (1) with isothiocyanates, the respective thiosemicarbazides 2a-g were obtained. Further cyclization with 2% NaOH led to formation of 4-substituted-3-(thiophene- 2-yl-methyl)-Delta2-1,2,4-triazoline-5-thiones (3a-g). These compounds showed promising antimycotic activity.
متن کاملSimple Preparation of N-Substituted 4-Arylpyrrolones.
eernpounds,2) This prompted us to devise a general synthetic method for N-substituted 4-arylpyrrolones. rv-Unsubstituted 4-(4-chlorophenyl)pyrrolone has been prepared from 4-bromo-3-(4-chlorophenyl)-2-butenoic acid with a largc excess ammonia water,i) However, the application of this method, using excess arnines in an aqueous so[ution, would be Iimited, rv-Substitutcd arylpyrrelones may be prep...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1988
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.36.495